Our research program leverages cutting-edge neuroscience technologies to deconstruct the reciprocal interactions between neural circuit function and alcohol-related behaviors in preclinical mouse models. Our current work focuses on how interneuron subtypes shape prefrontal cortical activity patterns relevant for binge alcohol drinking and how repeated exposure to alcohol modifies these circuits, ultimately leading to compulsive alcohol use. We take a multimodal experimental approach to our questions, integrating head-fixed and free moving mouse behavior, quantitative behavioral modeling, two-photon calcium imaging, fiber photometry, whole-cell electrophysiology, optogenetics, chemogenetics, RNA sequencing, and other techniques.