BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Rutgers Addiction Research Center (RARC) - ECPv6.7.0//NONSGML v1.0//EN
CALSCALE:GREGORIAN
METHOD:PUBLISH
X-WR-CALNAME:Rutgers Addiction Research Center (RARC)
X-ORIGINAL-URL:https://www.addiction.rutgers.edu
X-WR-CALDESC:Events for Rutgers Addiction Research Center (RARC)
REFRESH-INTERVAL;VALUE=DURATION:PT1H
X-Robots-Tag:noindex
X-PUBLISHED-TTL:PT1H
BEGIN:VTIMEZONE
TZID:America/New_York
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:20240310T070000
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:20241103T060000
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20240207T100000
DTEND;TZID=America/New_York:20240207T110000
DTSTAMP:20260423T073100
CREATED:20240205T185237Z
LAST-MODIFIED:20240205T185237Z
UID:6327-1707300000-1707303600@www.addiction.rutgers.edu
SUMMARY:CCNP Webinar with Dr. Peter Manza (NIAAA) - "Dopamine kinetics and brain function: insights from simultaneous PET-fMRI"
DESCRIPTION:The addictiveness of stimulant drugs such as methylphenidate (MP) depends crucially on how fast they raise dopamine in the brain. Yet the brain circuits underlying the rate dependency to drug reward have not been resolved. We used simultaneous PET-fMRI to link dynamic changes in brain dopamine signaling\, functional brain activity/connectivity\, and the self-reported experience of ‘high’ in 20 healthy adults receiving MP at different speeds: slow (oral 60mg) and fast (intravenous-IV 0.25mg/kg) doses in a double-blind\, counterbalanced\, placebo-controlled study. We estimated speed of striatal dopamine increases to oral and IV MP and then tested where brain activity/connectivity was associated with slow and fast dopamine kinetics. The two administrations produced dramatically different effects on brain functional activation and connectivity despite a comparable overall magnitude of dopamine increases. These data demonstrate how fast dopamine increases generate unique effects on brain function that have relevance for the addictive potential of drugs. \nPresenter: Peter Manza\nNational Institute oN Alcohol Abuse and Alcoholism (NIAAA)\nNational Institute of Health \nLocation/Logistics \n\nWednesday\, February 7\, 10-11am EST\nZoom link: https://princeton.zoom.us/j/6397147065\n\nAbstracts for previous talks are posted on the CCNP website: ccnp.princeton.edu. A list of upcoming seminars\, job announcements\, and other info about CCNP are available there as well.
URL:https://www.addiction.rutgers.edu/event/ccnp-webinar-with-dr-peter-manza-niaaa-dopamine-kinetics-and-brain-function-insights-from-simultaneous-pet-fmri/
LOCATION:Virtual
END:VEVENT
END:VCALENDAR